CD43Lo classical monocytes participate in the cellular immune response to isolated primary blast lung injury

BACKGROUNDUnderstanding of the cellular immune response to primary blast lung injury (PBLI) is limited, with only the neutrophil response well documented. Moreover, its impact on the immune response in distal organs remains poorly understood. In this study, a rodent model of isolated primary blast injury was used to investigate the acute cellular immune response to isolated PBLI in the circulation and lung, including the monocyte response, and investigate distal subacute immune effects in the spleen and liver 6 hours after injury.METHODSRats were subjected to a shock wave (~135 kPa overpressure, 2 ms duration) inducing PBLI or sham procedure. Rat physiology was monitored, and at 1, 3, and 6 hours thereafter, blood, lung, and bronchoalveolar lavage fluid (BALF) were collected and analyzed by flow cytometry, enzyme-linked immunosorbent assay, and histologic examination. In addition, at 6 hours, spleen and liver were collected and analyzed by flow cytometry.RESULTSLung histology confirmed pulmonary barotrauma and inflammation. This was associated with rises in CXCL-1, interleukin 6 (IL-6), tumor necrosis factor α and albumin protein in the BALF. Significant acute increases in blood and lung neutrophils and CD43Lo/His48Hi (classical) monocytes/macrophages were detected. No significant changes were seen in blood or lung “nonclassical” monocyte and in natural killler, B, or T cells. In the BALF, significant increases were seen in neutrophils, CD43Lo monocyte-macrophages and monocyte chemoattractant protein-1. Significant increases in CD43Lo and Hi monocyte-macrophages were detected in the spleen at 6 hours.CONCLUSIONThis study reveals a robust and selective response of CD43Lo/His48Hi (classical) monocytes, in addition to neutrophils, in blood and lung tissue following PBLI. An increase in monocyte-macrophages was also observed in the spleen at 6 hours. This profile of immune cells in the blood and BALF could present a new research tool for translational studies seeking to monitor, assess, or attenuate the immune response in blast-injured patients

De l'intégrateur neuronal oculomoteur aux oscillations rapides du cervelet

Doctorat en kinésithérapie et réadaptationinfo:eu-repo/semantics/nonPublishe

From biomechanics to sport psychology: The current oscillatory approach

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

De l'intégrateur neuronal oculomoteur aux oscillations rapides du cervelet

Doctorat en kinésithérapie et réadaptationinfo:eu-repo/semantics/nonPublishe

Is the frontal N30 component of the somatosensory evoked potentials a reliable physiological index of the dopaminergic motor pathways?

CommentEditorialinfo:eu-repo/semantics/publishe

How to Measure the Psychological “Flow”? A Neuroscience Perspective

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Effect of incisions in the brainstem commissural network on the short-term vestibulo-ocular adaptation of the cat.

This study was intended to test the adaptive plasticity of the vestibulo-ocular reflex before and after either a midsagittal or parasagittal incision in the brainstem. Eye movements were measured with the electromagnetic search coil technique during the vestibulo-ocular reflex (VORD) in the dark, the optokinetic reflex (OKN), and the visuo-vestibular adaptive training procedure. Two types of visual-vestibular combined stimulation were applied by means of low frequency stimuli (0.05 to 0.10 Hz). In order to increase or decrease the VORD gain, the optokinetic drum was oscillated either 180 degrees out-of-phase or in-phase with the vestibular stimulus turntable. This "training" procedure was applied for 4 hours. Initial measurements of the VORD were normal with a mean gain value of 0.92 +/- 0.08. After 4 hours of "training" with the out-of-phase condition (180 degrees), VORD gain reached mean values of 1.33 +/- 0.11 (n = 6 cats). In the in-phase combination, the mean VORD gain decreased from 1.0 to 0.63 +/- 0.02 (n = 2 cats). No significant change of VORD phase was found in any of the cats. Midsagittal or parasagittal pontomedullary brainstem incisions were performed in 4 cats. Recovery of the VOR was tested on the 2nd, 7th, and 30th day after operation. After the 30th day, recovery of the VORD gain stabilized at about 66% of the initial preoperative value. At this stage of the recovery, the optokinetic response (OKN) of the midsagittal-lesioned cats was practically normal: in the parasagittal-lesioned cats, the postoperative OKN responses were asymmetric. After stabilization of recovery, lesioned cats were trained with the same adaptation procedure. Although the direct effect of the visuo-vestibular combined stimulation during the training was still operative in all lesioned cats, the adaptive plasticity was completely abolished by the lesions. These results suggest that the commissural brainstem network may play a crucial role in the acquisition of the forced VOR adaptation.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

The belgian partners and GH thesis

info:eu-repo/semantics/publishe

Reconstructing cerebral palsy

Forty years ago, a consensual definition of the cerebral palsy concept was suggested, delineating it as a disorder of movement and posture secondary to non-progressive pathological processes that affect the immature brain. Because this concept is pragmatic and based on function, it has survived unaltered many changes in pathophysiolgical knowledge, diagnostic technology and general nosology. However, its basis has appeared to be flawed. Its main justification remains management, for which the need to meticulously select patients, define adapted objectives, design appropriate management programs and evaluate results has been increasingly recognized. Fine movement analysis using recent technologies can provide a wealth of information about neurological functioning in cerebral palsy that can serve these purposes. Specific patterns of motor organization reveal different modes of motor control in individuals with developmental motor problems. The different motor patterns reflect individual adaptation to the impairment of the central nervous system. Taken phenomenologically these patterns can contribute to the clinical approach to cerebral palsy and redefine patients groups within this framework. © 2004, IOS Press. All rights reserved.info:eu-repo/semantics/publishe

Le Mouvement -- 1

info:eu-repo/semantics/published